The breaking of the great horn indicates the breaking up of the monarchy of Alexander by his death. The four horns which grow up in the place of the one great horn are, according to Dan 8:22, four kingdoms. These are the dynasties of the Diadochs, of whom there were indeed five: Antigonus, Ptolemy, Cassander, and Lysimachus laid claim to the title of king; but for the first time after the overthrow of Antigonus at the battle of Ipsus, 301 b.c., and thus twenty-two years after the death of Alexander (323 b.c.), they became in reality four kings, and so divided the kingdom among themselves, that Lysimachus had Thrace and Bithynia, - Cassander, Macedonia and Greece, - Seleucus, Syria, Babylonia, and the Eastern countries as far as India, - and Ptolemy, Egypt, Palestine, and Arabia Petrea.