Spurgeon has five sermons on the passage:
"Substitution" (No. 141-2 in The New Park Street Pulpit) - July 19, 1857
"Christ--Our Substitute" (No. 310 in The New Park Street Pulpit) - April 15, 1860
"God Beseeching Sinners by His Minister" (No. 1124 in The Metropolitan Tabernacle Pulpit) - July 27, 1873
"The Heart of the Gospel" (No. 1910 in The Metropolitan Tabernacle Pulpit) - July 18, 1886
"Christ Made Sin" (No. 3203 in The Metropolitan Tabernacle Pulpit) - June 23, 1910*
(*Publication date, not delivery date)